I have read tons of dystopian future stories from the YA graphic novel market, and Odessa is one of the best ones, because it is well realized and complex. It begins when Ginny, the main character, gets a package for her 18th birthday. This package, it turns out, came from her mother Odessa, who has not been home in years and was presumed dead. This gift sets off an entire series of events that put Ginny on a quest across the environmental disaster the western United States has become to either find her mother or some sort of resolution to this situation. Along the way she runs into a good number of interesting folks (both friends and adversaries), including two stowaways that really up the stakes for her (and their) safety.
I am being vague because I do not want to spoil too much, but suffice it to say that I feel that the plot of this book is excellent, with lots of moments of suspense and cliffhangers (both emotional and physical), superb character designs, grand vistas of devastation, and palpable character moments. The way the book ends very much begs for a sequel, and I really hope we eventually get one.
One big reason why we have not gotten a sequel yet is that this book's creator, Jonathan Hill has been working on another graphic novel series, Tales of a Seventh-Grade Lizard Boy and its soon-to-be-published sequel Lizard Boy 2: The Most Perfect Summer Ever. He speaks about his work on Odessa in this interview.
All of the reviews I have read about this book have sung its praises. In a starred entry, Kirkus Reviews summed it up as "a gritty, raw page-turner." Sara Smith wrote, "There are parts of this story that are hauntingly beautiful." Becky Proie opined, "Odessa is a seemingly simple and effortless graphic novel that manages to take the well-used dystopian setting and somehow bring a welcoming feel to it that makes readers not want to put it down."
Odessa was published by Oni Press, and they offer more info about it here.